Now I would argue the Inuit have hardly faced any persecution by anyone. Most Inuit land is uninhabited and has always been unihabited by anyone other than the Inuit. They have there own self government in Canada and are pretty much an isolated autnomous nation within a larger country. Since they have no concept of nation or country they are fine with this. Really the Inuit have suffered the least of all aborginal native peoples in North America, the only big thing that has struck them would be the few introduced disease, alcohol (which is now banned in most Inuit communities) and us trying to get them to stop killing so many whales.

Now, if you want to discuss the Beothuk, MigMagh, Huron, Iroquois, Cherokee or any of the countless other tribes, than I will say that colonialism was devastating to them. Especially the Beothuk since, thanks to the Brits, they were the worlds first and only successful case of genocide.