When they held the WC in Mexico, many complained about the altitude and thin air making it impossible to play.
Well the game went on without any problem.

I don't think the heat will be a show stopper, they can simply schedule the matches in the evening or early mornin, erect a giant umbrella or air-condition the whole stadium.

I think the lack of infrastructures (need several international class stadium, public transport and accommodation) as well as the fact that the host country never qualified in the previous WC (no precedent, CMIIW) will be a bigger obstacle.