Type III may just possibly be due to the following:
Take a 46xy (male chromosomed) foetus. Under normal circumstances, a boy.
Then add high-grade Androgen Insensitivity Syndrome, so the cells aren't sensitive to Testosterone, the male sex hormone. The result will look female, possibly very female, and usually with a feminised brain. Testes will still be present, but ineffective, and internal. A short vagina and normal-ish clitoris. Basically, a sterile girl.
THEN add NonClassical Congenital Adrenal Hyperlasia. That will masculinise any foetus, 46xx or 46xy. It may not affect the brain though. The result will be something that looks almost normally male, but with a variety of anomalies. Might even be marginally fertile, but the lack of a normal penis would be a problem. There's be something there, but rather small for a penis, yet too large for a clitoris. A girl who looks mainly like a boy, but with a few anomalies.
Finally... administer a drug that will temporarily stop the symptoms of NC-CAH. The result will be something that looks male suddenly looking female. The hormonal chaos will cause rapid weight loss, and will usually be fatal. The genitalia will be a mess due to atrophy and shrinkage. Small, soft testes that will often retract internally, and the patient will have a shallow depth or short length, and an empty foreskin. A girl who mainly looks like a girl, and with a lot of anomalies.
That's the current theory anyway. I survived, obviously. AIS was diagnosed in 1985. NC-CAH recently. But it may be something else with the same symptoms.
April-May-June-September-October-November.
Quite a ride.
There is no situation so complex it can't get even worse
Type III may just possibly be due to the following:
Take a 46xy (male chromosomed) foetus. Under normal circumstances, a boy.
Then add high-grade Androgen Insensitivity Syndrome, so the cells aren't sensitive to Testosterone, the male sex hormone. The result will look female, possibly very female, and usually with a feminised brain. Testes will still be present, but ineffective, and internal. A short vagina and normal-ish clitoris. Basically, a sterile girl.
THEN add NonClassical Congenital Adrenal Hyperlasia. That will masculinise any foetus, 46xx or 46xy. It may not affect the brain though. The result will be something that looks almost normally male, but with a variety of anomalies. Might even be marginally fertile, but the lack of a normal penis would be a problem. There's be something there, but rather small for a penis, yet too large for a clitoris. A girl who looks mainly like a boy, but with a few anomalies.
Finally... administer a drug that will temporarily stop the symptoms of NC-CAH. The result will be something that looks male suddenly looking female. The hormonal chaos will cause rapid weight loss, and will usually be fatal. The genitalia will be a mess due to atrophy and shrinkage. Small, soft testes that will often retract internally, and the patient will have a shallow depth or short length, and an empty foreskin. A girl who mainly looks like a girl, and with a lot of anomalies.
That's the current theory anyway. I survived, obviously. AIS was diagnosed in 1985. NC-CAH recently. But it may be something else with the same symptoms.
April-May-June-September-October-November.
Quite a ride.
There is no situation so complex it can't get even worse